Ammonia → 7-Amino-5-azaspiro(2.4)heptan-4-one

HRID 342042

반응식

HRID 342042 반응식
[NH2:1][CH:2]([C:5]1([C:8]([O:10]CC)=O)[CH2:7][CH2:6]1)[C:3]#[N:4].N.[H][H]>[Ni]>[NH2:1][CH:2]1[C:5]2([CH2:7][CH2:6]2)[C:8](=[O:10])[NH:4][CH2:3]1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 110192531-(1-Amino-1-cyanomethyl)-1-ethoxycarbonylcyclopropaneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 109314407-Amino-5-azaspiro(2.4)heptan-4-one수율 92.3%

시약·촉매·용매 1

HCID 935Nickel촉매

실험 절차

An autoclave was charged with 1.0 g of 1-(1-amino-1-cyanomethyl)-1-ethoxycarbonylcyclopropane, 0.4 ml of Raney nickel and 4.0 ml of ammonia-saturated ethanol, and the contents were stirred at 80° C. for 4 hours in an atmosphere of hydrogen under a pressure of 20 kg/cm2. After completion of the reaction, the catalyst was removed by filtration and the resulting filtrate was concentrated under a reduced pressure to obtain 692 mg (92%) of the title compound in the form of colorless crystals. The thus obtained product was recrystallized from ethyl acetate and diethyl ether and used as a sample for analyses.

후처리

  1. customAfter completion of the reaction
  2. customthe catalyst was removed by filtration
  3. concentrationthe resulting filtrate was concentrated under a reduced pressure

출처 및 근거

ORD 기록
ord-c2687b77a6e949279a9d6710636a40e7
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05856518

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