Hydrochloric Acid → Methyl 1-isopropyl-1H-indole-6-carboxylate

HRID 342065노트

반응식

HRID 342065 반응식
CO[CH:3](OC)[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([O:13][CH3:14])=[O:12])=[CH:7][C:6]=1[NH:15][CH:16]([CH3:18])[CH3:17].Cl>CO>[C:11]([C:8]1[CH:7]=[C:6]2[C:5]([CH:4]=[CH:3][N:15]2[CH:16]([CH3:18])[CH3:17])=[CH:10][CH:9]=1)([O:13][CH3:14])=[O:12]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 193540554-Carbomethoxy-2-(N-2-propylamino)phenylacetaldehyde dimethylacetal

생성물 1

HCID 10608809Methyl 1-isopropyl-1H-indole-6-carboxylate수율 97.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

4-Carbomethoxy-2-(N-2-propylamino)phenylacetaldehyde dimethylacetal (3.7 g, 13.15 mmole) was refluxed with 100 mL of 1N hydrochloric acid in methanol for 1 h. The solution was concentrated and the residue dissolved in 50 mL of ethyl acetate, washed with saturated sodium bicarbonate solution, dried organic layer over magnesium sulfate and evaporated to give 2.78 g of 6-carbomethoxy-1-(2-propyl)indole.

후처리

  1. concentrationThe solution was concentrated
  2. dissolutionthe residue dissolved in 50 mL of ethyl acetate
  3. washwashed with saturated sodium bicarbonate solution, dried organic layer over magnesium sulfate
  4. customevaporated

출처 및 근거

ORD 기록
ord-8f100ba8036741fab008aba098d47ad9
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05856517

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