Acetamide → Acetaminophen

HRID 342171

반응식

HRID 342171 반응식
[C:1]1([CH:8]=[CH:7][C:5]([OH:6])=[CH:4][CH:3]=1)O.[C:9]([NH2:12])(=[O:11])[CH3:10]>O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.P.[W].[W].[W].[W].[W].[W].[W].[W].[W].[W].[W].[W]>[C:9]([NH:12][C:1]1[CH:8]=[CH:7][C:5]([OH:6])=[CH:4][CH:3]=1)(=[O:11])[CH3:10]

참가 물질

4

반응물 2

HCID 178AcetamideHCID 785Hydroquinone

생성물 1

HCID 1983Acetaminophen

시약·촉매·용매 1

HCID 45231312-Wolframophosphoric acid촉매

실험 절차

An intimate mixture of hydroquinone (5.5 g), acetamide (3.5 g) and phosphotungstic acid (0.3 g) was placed in a well stoppered stainless steel tube from which air has been displaced with nitrogen. The tube was kept in a temperature controlled oven at 280°-300° C. for 1.5 hrs. The tube was then removed from the oven, cooled, opened, contents extracted with ethyl acetate, crystallized and products analyzed by gas chromatography. Pure standard substances were used for calibration. The products were also analyzed and identified by GC-mass spectroscopy techniques. The conversion of hydroquinone was 95% by wt. and selectivity to N-acetyl para aminophenol was 86%. Pure N-acetyl para aminophenol could be isolated from the products by column chromatography using alumina.

후처리

  1. customThe tube was then removed from the oven
  2. temperaturecooled
  3. extractioncontents extracted with ethyl acetate
  4. customcrystallized

출처 및 근거

ORD 기록
ord-0a6d23bd603b4001be9243f7118d11a0
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05856575

연결된 노트

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