Ethyl Acetate → 1-(4-Bromo-phenyl)-isoquinolin-6-ol

HRID 342217

반응식

HRID 342217 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([O:18]C)=[CH:15][CH:16]=3)[CH:11]=[CH:10][N:9]=2)=[CH:4][CH:3]=1.C(OCC)(=O)C>C(O)(=O)C.Br>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=3)[CH:11]=[CH:10][N:9]=2)=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 8857Ethyl AcetateHCID 111415351-(4-Bromo-phenyl)-6-methoxy-isoquinoline

생성물 1

HCID 1361286691-(4-Bromo-phenyl)-isoquinolin-6-ol

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 260Hydrogen Bromide용매

실험 절차

The 1-(4-bromo-phenyl)-6-methoxy-isoquinoline obtained is boiled under reflux in 53 ml of acetic acid and 37 ml of 62% aqueous hydrobromic acid. Subsequently, after cooling to room temperature and addition of 150 ml of ethyl acetate the separated precipitate is filtered off. The crystals are washed with ethyl acetate and dried. There are obtained 7.6 g of 1-(4-bromo-phenyl)-isoquinolin-6-ol, MS: m/e 300 (M+H+, 1 Br).

후처리

  1. filtrationis filtered off
  2. washThe crystals are washed with ethyl acetate
  3. customdried

출처 및 근거

ORD 기록
ord-86d1d6104c494dc4936bdd7625021dfe
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05856503

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