Dimethylformamide → 1-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

HRID 342302

반응식

HRID 342302 반응식
[N+:1]([C:4]1[CH:23]=[CH:22][C:7]([C:8]([N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[C:14](=[O:21])[CH2:13][CH2:12][CH2:11]2)=[O:9])=[CH:6][CH:5]=1)([O-])=O.CN(C)C=O>[Ni].CO>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:8]([N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[C:14](=[O:21])[CH2:13][CH2:12][CH2:11]2)=[O:9])=[CH:22][CH:23]=1

참가 물질

5

반응물 2

HCID 6228DimethylformamideHCID 107337295H-1-Benzazepin-5-one, 1,2,3,4-tetrahydro-1-(4-nitrobenzoyl)-

생성물 1

HCID 107078741-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

A 19.2 g portion of 1-(4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one was dissolved in a mixed solvent consisting of 200 ml of dimethylformamide and 100 ml of methyl alcohol, and 3 ml of Raney nickel was added to the resulting solution to carry out hydrogenation at normal pressure. After completion of the hydrogen absorption, the reaction solution was filtered and concentrated. The thus obtained residue was dissolved in dichloromethane and then washed with a saturated sodium bicarbonate aqueous solution. The resulting dichloromethane layer was dried over anhydrous magnesium sulfate and then concentrated under a reduced pressure. The thus obtained residue was recrystallized from methyl alcohol to obtain 15.5 g of 1-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one.

후처리

  1. additionwas added to the resulting solution
  2. customAfter completion of the hydrogen absorption
  3. filtrationthe reaction solution was filtered
  4. concentrationconcentrated
  5. dissolutionThe thus obtained residue was dissolved in dichloromethane
  6. washwashed with a saturated sodium bicarbonate aqueous solution
  7. dry with materialThe resulting dichloromethane layer was dried over anhydrous magnesium sulfate
  8. concentrationconcentrated under a reduced pressure
  9. customThe thus obtained residue was recrystallized from methyl alcohol

출처 및 근거

ORD 기록
ord-d5417cc0bca1463e9be0ec527097a3b6
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05856564

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