Water → pentan-3-one O-(2-nitrophenyl)oxime

HRID 342410

반응식

HRID 342410 반응식
[CH3:1][CH2:2][C:3](=[N:6][OH:7])[CH2:4][CH3:5].[H-].[Na+].F[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N+:17]([O-:19])=[O:18].O>CN(C)C=O>[N+:17]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[O:7][N:6]=[C:3]([CH2:4][CH3:5])[CH2:2][CH3:1])([O-:19])=[O:18]

참가 물질

6

반응물 4

HCID 962WaterHCID 24758Sodium hydrideHCID 738951-Fluoro-2-nitrobenzeneHCID 28017453-Pentanone oxime

생성물 1

HCID 53768417pentan-3-one O-(2-nitrophenyl)oxime수율 111.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

To a solution of pentan-3-one oxime (6.00 g) in dimethylformamide (30 ml) was added sodium hydride (60% oil suspension, 2.37 g) under ice cooling. After 15 minutes, to the above mixture was added dropwise 1-fluoro-2-nitrobenzene (5.98 g) in dimethylformamide (30 ml). The mixture was stirred for 3 hours at ambient temperature and poured into a mixture of ice and water. The separated oil was extracted with diethyl ether. The organic layer was washed with water, dried over sodium sulfate and evaporated in vacuo to give pentan-3-one O-(2-nitrophenyl)oxime (10.51 g) as a brown oil.

후처리

  1. extractionThe separated oil was extracted with diethyl ether
  2. washThe organic layer was washed with water
  3. dry with materialdried over sodium sulfate
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-639adc713648416286868651f74f44a8
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05858995

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