Water → 2-(2-Bromophenoxy)cyclohexanone
반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].C(=O)([O-])[O-].[K+].[K+].Cl[CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][C:17]1=[O:22].O>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][C:17]1=[O:22]참가 물질
6
반응 조건
- 온도
- 60 °C
실험 절차
A mixture of 2-bromophenol (5 g), potassium carbonate (5.99 g) and 2-chlorocyclohexanone (4.22 g) in N,N-dimethylformamide was stirred at 60° C. for 4 hours. The reaction mixture was poured into cold water and the separated oil was extracted with diethyl ether. The extract was washed with water, dried over sodium sulfate and concentrated in vacuo. The residue was crystallized from n-hexane to give 2-(2-bromophenoxy)cyclohexanone (4.36 g).
후처리
- extractionthe separated oil was extracted with diethyl ether
- washThe extract was washed with water
- dry with materialdried over sodium sulfate
- concentrationconcentrated in vacuo
- customThe residue was crystallized from n-hexane
출처 및 근거
- ORD 기록
- ord-fdcd539dee8f43d48f694902bcd48d5f
- 출처 데이터셋
- uspto-grants-1999_01
- 특허 번호
- US05858995
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