Water → HCID 70197022, 화합물

HRID 342427

반응식

HRID 342427 반응식
[CH:1]([C:3]1[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[C:5]=2[O:6][C:7]=1[CH3:8])=[O:2].[BH4-].[Na+].O>CO>[OH:2][CH2:1][C:3]1[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[C:5]=2[O:6][C:7]=1[CH3:8]

참가 물질

5

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 867535523-Formyl-2-methyl-7-nitrobenzo[b]furan

생성물 1

HCID 70197022HCID 70197022, 화합물수율 74.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 3-formyl-2-methyl-7-nitrobenzo[b]furan (1.83 g) and sodium borohydride (200 mg) in methanol (40 ml) was stirred at ambient temperature for 2 hours. The reaction mixture was poured into cold water. The separated oil was extracted with dichloromethane. The extract was washed with brine, dried and evaporated in vacuo. The residue was purified by column chromatography on silica gel to give 3-hydroxymethyl-2-methyl-7-nitrobenzo[b]furan (1.38 g) as a solid.

후처리

  1. extractionThe separated oil was extracted with dichloromethane
  2. washThe extract was washed with brine
  3. customdried
  4. customevaporated in vacuo
  5. customThe residue was purified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-37724ab1656547ecbe4ee241eb8c5182
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05858995

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