HCID 3991306, 화합물 → 3-benzyl-5-methyl-1H-pyrimidine-2,4-dione
반응식
C([N:8]1[CH:13]=[C:12]([CH3:14])[C:11](=[O:15])[N:10]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:9]1=[O:23])C1C=CC=CC=1>[Pd].C([O-])=O.[NH4+]>[CH2:16]([N:10]1[C:11](=[O:15])[C:12]([CH3:14])=[CH:13][NH:8][C:9]1=[O:23])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1참가 물질
4
실험 절차
A mixture of 1,3-dibenzyl-5-methyl-2,4(1H,3H)-pyrimidinedione (2 g, 6.5 mmol), 5% palladium on carbon (3 g) and 0.4N ammonium formate (250 mL in methanol) was heated 1.5 hours at reflux. The reaction mixture then was filtered and concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with methylene chloride/methanol (95:5) to give 3-benzyl-5-methyl-2,4(1H,3H)-pyrimidinedione, m.p. 208°-210° C.
후처리
- temperaturewas heated 1.5 hours
- temperatureat reflux
- filtrationThe reaction mixture then was filtered
- concentrationconcentrated in vacuo
- customThe residue was purified by column chromatography on silica gel eluting with methylene chloride/methanol (95:5)
출처 및 근거
- ORD 기록
- ord-967537bb05594edb93591d4f289536eb
- 출처 데이터셋
- uspto-grants-1999_01
- 특허 번호
- US05859014
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