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Water → 8-(2,6-Dichloro-3-nitrobenzyloxy)-2-methylquinoline

HRID 342612
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인쇄 미리보기

반응식

HRID 342612 반응식
C([O-])([O-])=O.[Cs+].[Cs+].[OH:7][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:17]=1[N:16]=[C:15]([CH3:18])[CH:14]=[CH:13]2.[Cl:19][C:20]1[C:27]([N+:28]([O-:30])=[O:29])=[CH:26][CH:25]=[C:24]([Cl:31])[C:21]=1[CH2:22]Br.O>CN(C=O)C>[Cl:19][C:20]1[C:27]([N+:28]([O-:30])=[O:29])=[CH:26][CH:25]=[C:24]([Cl:31])[C:21]=1[CH2:22][O:7][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:17]=1[N:16]=[C:15]([CH3:18])[CH:14]=[CH:13]2
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 10796Cesium carbonateHCID 132242-Methyl-8-hydroxyquinolineHCID 110115352,6-Dichloro-3-nitrobenzyl Bromide

생성물 1

HCID 104989148-(2,6-Dichloro-3-nitrobenzyloxy)-2-methylquinoline

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Cs2CO3 (10.8 g, 33.3 mmol) was added at room temperature to 8-hydroxy-2-methylquinoline (5 g, 33.3 mmol) in DMF (65 ml). After 30 min, 2,6-dichloro-3-nitrobenzyl bromide (13 g, 45.6 mmol) was added. After 18 h, H2O was added and the precipitate was filtered off with suction and washed with EA (50 ml), the title compound being obtained as an amorphous substance.

후처리

  1. waitAfter 18 h
  2. filtrationthe precipitate was filtered off with suction
  3. washwashed with EA (50 ml)

출처 및 근거

ORD 기록
ord-a8be8013f9e0459f8433499fad2dcbee
출처 데이터셋
uspto-grants-1999_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05859025

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