Water → 4-Methylsulfonylacetophenone

HRID 342647

반응식

HRID 342647 반응식
[OH:1]OS([O-])=O.[K+].C(N([CH2:23][C:24]([OH:26])=O)CC(O)=O)CN(CC(O)=O)CC(O)=O.[CH3:27][C:28]1[CH:29]=[C:30]([C:33](=O)[CH3:34])[S:31][CH:32]=1.S(S([O-])=O)([O-])(=O)=O.[Na+].[Na+].[OH2:45]>CC(C)=O>[CH3:32][S:31]([C:30]1[CH:33]=[CH:34][C:27]([C:24](=[O:26])[CH3:23])=[CH:28][CH:29]=1)(=[O:1])=[O:45]

참가 물질

7

반응물 5

HCID 962Water3회HCID 6049Ethylenediaminetetraacetic AcidHCID 836541-(4-Methyl-2-thienyl)ethan-1-oneHCID 656671Sodium PyrosulfiteHCID 23707502Potassium hydroxy sulfite

생성물 1

HCID 825294-Methylsulfonylacetophenone

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A solution of 1036 g of oxone and 11.7 g of EDTA (Ethylene diamine tetraacetic acid) dissolved in 3.8 l of water is added dropwise to a solution of (4-methylthiophenyl)ethanone (prepared according to J. Am. Chem. Soc. 1952 p. 5475) in 1 l of acetone and 1.1 l of water, the temperature being kept below 32° C. The reaction mixture is stirred for 16 h after the end of the addition, then 550 g of sodium metabisulphite are added portionwise. The reaction mixture is then filtered, the solid obtained is taken up in water, dried in the oven and recrystallised from ethanol.

후처리

  1. custombeing kept below 32° C
  2. additionafter the end of the addition
  3. filtrationThe reaction mixture is then filtered
  4. customthe solid obtained
  5. customdried in the oven
  6. customrecrystallised from ethanol

출처 및 근거

ORD 기록
ord-9d0b9ce9dd594b1b83638059fc6fe3bc
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05859036

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