Ethanol → Ethyl 2-Aminobutyrate Hydrochloride

HRID 342864

반응식

HRID 342864 반응식
S(Cl)([Cl:3])=O.[NH2:5][CH:6]([CH2:10][CH3:11])[C:7]([OH:9])=[O:8].[CH2:12](O)[CH3:13]>>[ClH:3].[NH2:5][CH:6]([CH2:10][CH3:11])[C:7]([O:9][CH2:12][CH3:13])=[O:8]

참가 물질

4

반응물 3

HCID 702EthanolHCID 6657Alpha-Aminobutyric AcidHCID 24386Thionyl Chloride

생성물 1

HCID 12844023Ethyl 2-Aminobutyrate Hydrochloride수율 97%

반응 조건

온도
27 °C

실험 절차

Thionyl chloride (1.25 moles) was added to a solution of 2-aminobutyric acid (1 mole) in SD12A3 (95% ethanol/5% toluene) at a temperature of <5° C. When addition was complete, the mixture was stirred at 27° C. for 16 hours and the resulting precipitate filtered off and washed with methyl t-butyl ether to give the desired product as a white solid (97% yield).

후처리

  1. additionWhen addition
  2. filtrationthe resulting precipitate filtered off
  3. washwashed with methyl t-butyl ether

출처 및 근거

ORD 기록
ord-57d667095fe445b4895e42c5c900e60d
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05859240

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