Chlorosulfonic acid → (R)-2-Butyl-2-ethylaziridine

HRID 342869노트

반응식

HRID 342869 반응식
ClS(O)(=O)=O.[CH2:6]([C:10]1([CH2:13][CH3:14])[CH2:12][NH:11]1)[CH2:7][CH2:8][CH3:9]>ClC(Cl)C>[CH2:6]([C@:10]1([CH2:13][CH3:14])[CH2:12][NH:11]1)[CH2:7][CH2:8][CH3:9]

참가 물질

4

반응물 2

HCID 24638Chlorosulfonic acidHCID 217099702-Butyl-2-ethylaziridine

생성물 1

HCID 53812986(R)-2-Butyl-2-ethylaziridine수율 77%

시약·촉매·용매 1

HCID 63651,1-Dichloroethane용매

실험 절차

Chlorosulphonic acid (1 molar equivalent) was added to a solution of the product from step (f) (15 g) in dichloroethane (90 ml) at a temperature of <16° C. When addition was complete, the mixture was stirred for 2 hours at room temperature and then evaporated in vacuo. Water (60 ml) and 5% w/v aqu. NaOH (41 ml) were added and the mixture distilled at atmospheric pressure. The organic phase of the distillate was separated and dried over KOH to give a solution of the desired product (77% yield).

후처리

  1. additionWhen addition
  2. customevaporated in vacuo
  3. additionNaOH (41 ml) were added
  4. distillationthe mixture distilled at atmospheric pressure
  5. customThe organic phase of the distillate was separated
  6. dry with materialdried over KOH

출처 및 근거

ORD 기록
ord-bcd591f56ef74c39a95b82a1fd46c7ab
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05859240

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