2-Aminopropanol → 2-(N-Hexadecanoyl)amino-1-propanol

HRID 34304

반응식

HRID 34304 반응식
[CH3:1][CH:2]([NH2:5])[CH2:3][OH:4].[C:6](Cl)(=[O:22])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>C(Cl)Cl>[C:6]([NH:5][CH:2]([CH3:1])[CH2:3][OH:4])(=[O:22])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]

참가 물질

4

반응물 2

HCID 51262-AminopropanolHCID 8206Palmitoyl chloride

생성물 1

HCID 184318022-(N-Hexadecanoyl)amino-1-propanol수율 51%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 4.00 g (53.2 mmol) of commercially obtained dl-2-amino-1-propanol b and 8.0 g (8.8 ml, 29.3 mmol) of hexadecanoyl chloride in 100 ml of CH2Cl2 was stirred at room temperature for hours. The solution was concentrated and the residue was boiled with 200 ml acetone and decanted. The solution was concentrated and the residue was chromatographed on silica gel using 50% ethylacetate in hexane to afford 4.15 g (51%) of the title compound as white needles, m.p. 75-76° C. Using the same procedure as in Example 19, the following compounds were prepared:

후처리

  1. concentrationThe solution was concentrated
  2. customdecanted
  3. concentrationThe solution was concentrated
  4. customthe residue was chromatographed on silica gel using 50% ethylacetate in hexane

출처 및 근거

ORD 기록
ord-9fed08b7a87d4dc89a917158d7429c2c
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04761404

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