2-Phenylacetophenone → 1,2-Diphenyl-1-ethanone oxime

HRID 343089

반응식

HRID 343089 반응식
[C:1]1([C:7]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:17][OH:18].O.O.O.C([O-])(=O)C.[Na+]>C(O)C.O>[C:1]1([C:7](=[N:17][OH:18])[CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

6

반응물 3

HCID 99482-PhenylacetophenoneHCID 443297Hydroxyamine hydrochlorideHCID 23665404Sodium Acetate Trihydrate

생성물 1

HCID 2353831,2-Diphenyl-1-ethanone oxime수율 95%

시약·촉매·용매 2

HCID 702Ethanol용매2회HCID 962Water용매

실험 절차

A solution of deoxybenzoin (407.4 g, 2.076 mol) in 2 L of absolute ethanol and 600 mL of water was treated with hydroxylamine hydrochloride (288 g, 4.15 mol) and sodium acetate trihydrate (564 g, 4.15 mol). The solution was then warmed to reflux for 2 hours. The reaction mixture was then diluted with 1000 mL of 30% aqueous ethanol and allowed to cool to room temperature whereupon crystals of pure oxime formed which were isolated by filtration and air dried to afford 415.4 g, 95%, mp 94°-96° C. of pure deoxybenzoin oxime.

후처리

  1. temperatureThe solution was then warmed
  2. temperatureto reflux for 2 hours
  3. customformed which
  4. customwere isolated by filtration and air
  5. customdried

출처 및 근거

ORD 기록
ord-bd13a5f5f72e4db9ba33ba95fdd8b9fb
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05859257

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