3-Aminothiophenol → 3-(4-Methoxy phenylmethylthio)phenylamine

HRID 34324

반응식

HRID 34324 반응식
[Na].[NH2:2][C:3]1[CH:4]=[C:5]([SH:9])[CH:6]=[CH:7][CH:8]=1.[CH3:10][O:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16]Cl)=[CH:14][CH:13]=1>CN(C=O)C.C(#N)C>[CH3:10][O:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][S:9][C:5]2[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=2)[NH2:2])=[CH:14][CH:13]=1

참가 물질

6

반응물 3

HCID 315773-AminothiophenolHCID 699934-Methyloxybenzyl chlorideHCID 5360545Sodium

생성물 1

HCID 137451443-(4-Methoxy phenylmethylthio)phenylamine

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 6342Acetonitrile용매

실험 절차

Sodium ydride (99%, 8.22 g) was added in portions of a stirred solution of 3-aminothiophenol (44.23 g) in dry DMF (132 ml) at 0° . After 30 minutes a solution of 4-methoxybenzyl chloride (53.61 g) in acetonitrile (132 ml) was added dropwise and the mixture was stirred 30 minutes at 0° and 1 hour more at ambient temperature. The mixture was poured into ice-water (200 ml) and the resulting solid was collected by filtration and dried in air to provide the title compound, m.p. 85°-86°.

후처리

  1. filtrationthe resulting solid was collected by filtration
  2. customdried in air

출처 및 근거

ORD 기록
ord-6ded6b0d782d4f37b474565d4db4898f
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04761425

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