Methanol → HCID 13744932, 화합물

HRID 34325노트

반응식

HRID 34325 반응식
Cl[C:2]1[C:11]([C:12]([O:14][CH2:15]C)=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][C:6]([S:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)=[CH:7][CH:8]=2)[N:3]=1.[Na].[CH3:28][OH:29]>C(Cl)Cl>[CH3:28][O:29][C:2]1[C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][C:6]([S:17][CH2:18][C:19]3[CH:20]=[CH:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=3)=[CH:7][CH:8]=2)[N:3]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 5360545SodiumHCID 13744931Ethyl 2-chloro-7-(4-methoxyphenylmethylthio)quinolin-3-carboxylate

생성물 1

HCID 13744932HCID 13744932, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The ester from Step 3 (7.76 g) was added to a solution of sodium (920 mg) in anhydrous methanol (50 ml) and the resulting suspension was refluxed under an argon atmosphere for 75 minutes. The mixture was cooled, diluted with CH2Cl2 (200 ml), washed with water (3×50 ml) and reduced to dryness to provide the title compound, m.p. 133°-134.5°.

후처리

  1. temperaturethe resulting suspension was refluxed under an argon atmosphere for 75 minutes
  2. temperatureThe mixture was cooled
  3. washwashed with water (3×50 ml)

출처 및 근거

ORD 기록
ord-9b4fcb92c3a540a2a1e2a1fe20f8ad8a
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04761425

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