Sodium hydride → 2-(2-oxopyrrolidin-1-yl)-N-(3-methyl-5,6,7,8-tetrahydrothieno[2,3-b]quinolin-4-yl)acetamide

HRID 343343

반응식

HRID 343343 반응식
[H-].[Na+].[NH2:3][C:4]1[C:13]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=2[N:7]=[C:6]2[S:14][CH:15]=[C:16]([CH3:17])[C:5]=12.[O:18]=[C:19]1[CH2:23][CH2:22][CH2:21][N:20]1[CH2:24][C:25](OC)=[O:26].[Cl-].[NH4+]>CN1CCCC1=O>[O:18]=[C:19]1[CH2:23][CH2:22][CH2:21][N:20]1[CH2:24][C:25]([NH:3][C:4]1[C:13]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=2[N:7]=[C:6]2[S:14][CH:15]=[C:16]([CH3:17])[C:5]=12)=[O:26]

참가 물질

6

반응물 4

HCID 24758Sodium hydrideHCID 25517Ammonium ChlorideHCID 108835Methyl 2-oxo-1-pyrrolidineacetateHCID 152251184-Amino-3-methyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline

생성물 1

HCID 153850712-(2-oxopyrrolidin-1-yl)-N-(3-methyl-5,6,7,8-tetrahydrothieno[2,3-b]quinolin-4-yl)acetamide

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

반응 조건

온도
50 °C

실험 절차

Into a suspension of 1.26 g of sodium hydride (60% content) in 15 ml of N-methylpyrrolidone, was added 3.28 g of 4-amino-3-methyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline at room temperature. The mixture was heated to 50° C. and stirred for 40 minutes. Thereafter, 4.72 g of methyl 2-oxo-1-pyrrolidine acetate was added dropwise to the mixture at 50° C. over a period of 30 minutes. After the stirrng at 50° C. for 20 minutes, the mixture was cooled to 15° C. and poured into 130 ml aqueous solution containing 13.5 g of ammonium chloride.

후처리

  1. waitAfter the stirrng at 50° C. for 20 minutes
  2. temperaturethe mixture was cooled to 15° C.

출처 및 근거

ORD 기록
ord-8ef3663b434044298bab24f903f6e607
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05861411

연결된 노트

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