Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Bromide → 1-Benzyl-4-cyano-4-phenylpiperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Phenylpiperidine-4-carbonitrile hydrochloride | HCID 3084973 | — |
| 용매 | Oxolane--water (1/1) | HCID 21881883 | — |
| 생성물 | 1-Benzyl-4-cyano-4-phenylpiperidine | HCID 191408 | — |
반응 단계
Alternately, combine 4-phenyl-4-cyano-piperidine hydrochloric acid salt (10 g, 44.9 mmol), benzyl bromide (5.4 mL, 45.4 mmol), and potassium carbonate (25.2g, 182.3 mmol) in tetrahydrofuran/water (80 mL/20 mL). After 18 hours, partition the reaction mixture between water and dichloromethane. Separate The organic layer and extract with water, dry over MgSO4, filter and evaporate invacuo to give a residue. Recrystallize the residue from hexane to give 1-benzyl-4-phenyl-4-cyanopiperidine as a solid: mp; 73°-74° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05861417 |
| 출처 데이터셋 | uspto-grants-1999_01 |
| ORD ID | ord-6af9594e2cda42c1a919923860343293 |
| 출처 메모 | uspto-grants-1999_01 |