Triethylamine → HCID 11436590, 화합물

HRID 343600

반응식

HRID 343600 반응식
[CH2:1]([NH:3][CH2:4][C:5]([OH:7])=O)[CH3:2].[CH3:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[C:10]=1[N:16]=[C:17]=[S:18].C(N(CC)CC)C>C(Cl)Cl>[CH3:15][C:11]1[CH:12]=[CH:13][CH:14]=[C:9]([CH3:8])[C:10]=1[N:16]1[C:5](=[O:7])[CH2:4][N:3]([CH2:1][CH3:2])[C:17]1=[S:18]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 879762,6-Xylyl isothiocyanateHCID 316542N-Ethylglycine

생성물 1

HCID 11436590HCID 11436590, 화합물수율 18.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of N-ethyl glycine (9.2 g), 2,6-dimethylphenyl-isothiocyanate (8.2 g), triethylamine (10.1 g), and methylene chloride (150 mL) was heated at reflux for 3.5 hours. The mixture was evaporated to dryness. Purification was achieved through crystallization from ethanol. The title compound (2.3 g) was obtained as a white solid (2.3 g). m.p. 128°-131° C. Anal. Calcd. for. C13H16N2OS: C, 62.87; H, 6.49; N, 11.28. Found: C, 62.83; H, 6.50; N, 11.25. Mass spectrum (EI, M.+) m/z 248.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 3.5 hours
  3. customThe mixture was evaporated to dryness
  4. customPurification
  5. customwas achieved through crystallization from ethanol

출처 및 근거

ORD 기록
ord-497f500330044158bb46447d68ff46cf
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05861517

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