Triethylamine → 1-Ethyl-3-(2-ethyl-6-methylphenyl)-2-thioxo-imidazolidin-4-one

HRID 343604노트

반응식

HRID 343604 반응식
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:4]=1[N:10]=[C:11]=[S:12])[CH3:2].[CH2:13]([NH:15][CH2:16][C:17](O)=[O:18])[CH3:14].C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH2:13]([N:15]1[CH2:16][C:17](=[O:18])[N:10]([C:4]2[C:5]([CH3:9])=[CH:6][CH:7]=[CH:8][C:3]=2[CH2:1][CH3:2])[C:11]1=[S:12])[CH3:14]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 1441882-Ethyl-6-methylphenyl isothiocyanateHCID 316542N-Ethylglycine

생성물 1

HCID 114255061-Ethyl-3-(2-ethyl-6-methylphenyl)-2-thioxo-imidazolidin-4-one

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

The title compound was prepared by the procedure described in Example 10 using 17.7 g of 2-ethyl-6-methylphenyl-isothiocyanate, 18.4 g of N-ethyl glycine, 20.2 g of triethyl amine, and 300 mL of chloroform. The residue was further purified by flash chromatography on silica gel (20% ethyl acetate in hexane). The title compound was obtained (8.6 g) as a light peach solid, m.p. 82°-84° C. Anal. Calcd. for. C14H18N2OS: C, 64.09; H, 6.92; N, 10.68. Found: C, 64.27; H, 7.04; N, 10.60. Mass spectrum (EI, M.+) m/z 262.

후처리

  1. customThe title compound was prepared by the procedure
  2. customThe residue was further purified by flash chromatography on silica gel (20% ethyl acetate in hexane)

출처 및 근거

ORD 기록
ord-aef38b9ed491445e8e85a5297bb3b5a7
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05861517

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