Sodium Hydroxide → 2-(3-(Propan-2-yloxy)phenyl)acetic acid

HRID 343681노트

반응식

HRID 343681 반응식
C([O:4][C:5](=[O:17])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH:14]([CH3:16])[CH3:15])[CH:8]=1)(C)C.[OH-].[Na+]>C(O)C.O>[CH:14]([O:13][C:9]1[CH:8]=[C:7]([CH2:6][C:5]([OH:17])=[O:4])[CH:12]=[CH:11][CH:10]=1)([CH3:16])[CH3:15]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 54166898Isopropyl 2-(3-isopropoxyphenyl)acetate

생성물 1

HCID 166389242-(3-(Propan-2-yloxy)phenyl)acetic acid

시약·촉매·용매 1

HCID 19096565Water ethanol용매

실험 절차

Combine 3-isopropoxy-phenyl-acetic acid isopropyl ester 10.2 g, 43.2 mmol) and sodium hydroxide (2.08 g, 51.8 mmol) in 1/1 ethanol/water (80 mL). Heat to reflux. After 18 hours, remove the ethanol by evaporation in vacuo and acidify to pH=1 using an aqueous solution with 1M hydrochloric acid solution. Extract the aqueous solution 3 times with ethyl acetate. Extract the combined organic layers with water and saturated sodium chloride solution. Dry the organic layer over MgSO4, filter, and evaporate in vacuo to obtain 3-isopropoxy-phenyl-acetic acid.

후처리

  1. temperatureHeat to reflux
  2. customremove the ethanol
  3. customby evaporation in vacuo
  4. extractionExtract the aqueous solution 3 times with ethyl acetate
  5. extractionExtract the combined organic layers with water and saturated sodium chloride solution
  6. dry with materialDry the organic layer over MgSO4
  7. filtrationfilter
  8. customevaporate in vacuo

출처 및 근거

ORD 기록
ord-70dfd92320f74292bee62f28536705b2
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05861416

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