2-Amino-4-methyl-3-nitropyridine → 4-Methylpyridine-2,3-diamine

HRID 343787

반응식

HRID 343787 반응식
[NH2:1][C:2]1[C:7]([N+:8]([O-])=O)=[C:6]([CH3:11])[CH:5]=[CH:4][N:3]=1>[Ni].C(O)C>[NH2:1][C:2]1[C:7]([NH2:8])=[C:6]([CH3:11])[CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 1

HCID 2431662-Amino-4-methyl-3-nitropyridine

생성물 1

HCID 3174954-Methylpyridine-2,3-diamine수율 100.1%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

A mixture of 2-amino-4-methyl-3-nitropyridine (919 mg, 6.0 mmol), ethanol (20 mL) and Raney Ni (about 200 mg) was shaken under H2 (30-40 psi) for 1 h, then filtered. The filtrate was evaporated to dryness, giving 740 mg (100%) of the diamine 56, mp 114°-5° C. 1H NMR (DMSO-d6), 1.997 (s, 3H), 4.359 (s, 2H), 5.250 (s, 2H), 6.264 (d, 1H, J=3), 7.173 (d, 1H, J=3).

후처리

  1. filtrationfiltered
  2. customThe filtrate was evaporated to dryness

출처 및 근거

ORD 기록
ord-1e4b7f11e209442baf9dfc44a2f7158a
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05863916

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