Ammonia → 2-Amino-5-chloro-3-nitrobenzotrifluoride
반응식
[N+:1]([C:4]1[C:5](Cl)=[C:6]([C:11]([F:14])([F:13])[F:12])[CH:7]=[C:8]([Cl:10])[CH:9]=1)([O-:3])=[O:2].[NH3:16]>[Cl-].C([N+](CC)(CC)CC)C.O>[NH2:16][C:5]1[C:4]([N+:1]([O-:3])=[O:2])=[CH:9][C:8]([Cl:10])=[CH:7][C:6]=1[C:11]([F:14])([F:13])[F:12]참가 물질
5
반응 조건
- 온도
- 130 °C
실험 절차
260 g of 3-nitro-2,5-dichlorobenzotrifluoride, 130 ml of water and 10 g of tetraethylammonium chloride were introduced into an autoclave, and 120 ml of liquid ammonia were injected. The mixture was then heated to 130° C. and stirred for 10 hours at this temperature. After cooling, the batch was filtered and the precipitate which had been separated off was washed with water and dried. 194 g of 2-amino-3-nitro-5-chloro-benzotrifluoride with a melting point of 67° C. were obtained.
후처리
- temperatureAfter cooling
- filtrationthe batch was filtered
- customthe precipitate which had been separated off
- washwas washed with water
- customdried
출처 및 근거
- ORD 기록
- ord-e45f04a2d69a4d4fba4ee5d64ca4fe84
- 출처 데이터셋
- uspto-grants-1999_01
- 특허 번호
- US05863933
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