(+/-)-5-(2,5-Dioxo-4-imidazolidinylmethyl)-3-(1-methyl-4-piperidyl)-1H-indole → (+/-)-3-[3-(1-Methyl-4-piperidyl)-1H-indol-5-yl]alanine

HRID 343898

반응식

HRID 343898 반응식
O=C1[NH:6][CH:5]([CH2:7][C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[NH:13][CH:12]=[C:11]3[CH:17]2[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]2)[C:4](=[O:24])N1.[OH2:25].[OH-].[Ba+2].[OH-]>O>[CH3:23][N:20]1[CH2:21][CH2:22][CH:17]([C:11]2[C:10]3[C:14](=[CH:15][CH:16]=[C:8]([CH2:7][C@@H:5]([C:4]([OH:24])=[O:25])[NH2:6])[CH:9]=3)[NH:13][CH:12]=2)[CH2:18][CH2:19]1

참가 물질

4

반응물 2

HCID 15233277(+/-)-5-(2,5-Dioxo-4-imidazolidinylmethyl)-3-(1-methyl-4-piperidyl)-1H-indoleHCID 17749100Barium hydroxide, monohydrate

생성물 1

HCID 22852202(+/-)-3-[3-(1-Methyl-4-piperidyl)-1H-indol-5-yl]alanine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of the product from step (d) (2.4 g) and barium hydroxide hydrate (8.4 g) in water (50 ml) was refluxed for 72 hours, then cooled and evaporated in vacuo. The residue was taken up in hot methanol and filtered to remove barium salts.

후처리

  1. temperaturecooled
  2. customevaporated in vacuo
  3. filtrationfiltered
  4. customto remove barium salts

출처 및 근거

ORD 기록
ord-318bfde53829421087aea779f67bc012
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05863935

연결된 노트

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