Zolmitriptan → 3-Des[2-(Dimethylamino)ethyl] Zolmitriptan Acetonitrile
반응식
C[N:2]([CH2:4][CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH2:15][C@H:16]3[CH2:20][O:19][C:18](=[O:21])[NH:17]3)[CH:13]=2)[NH:8][CH:7]=1)C>C(Cl)(Cl)Cl>[C:4]([CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH2:15][C@H:16]3[CH2:20][O:19][C:18](=[O:21])[NH:17]3)[CH:13]=2)[NH:8][CH:7]=1)#[N:2]참가 물질
3
실험 절차
A solution of the product from step (b) (2.5 g) and polyphosphate ester (20.0 g) in chloroform (40 ml) was refluxed for 20 minutes. Ice was added to the cooled mixture and the chloroform evaporated in vacuo. The remaining aqueous phase was extracted with ethyl acetate and the combined extracts evaporated in vacuo to give the desired product as a pale yellow oil (1.8 g).
후처리
- additionIce was added to the cooled mixture
- customthe chloroform evaporated in vacuo
- extractionThe remaining aqueous phase was extracted with ethyl acetate
- customthe combined extracts evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-63574b24f08040b983c7e8b1e3350c7d
- 출처 데이터셋
- uspto-grants-1999_01
- 특허 번호
- US05863935
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