5-[4-Cyano-2-(2-phenylethynyl)phenyl]hydantoin → 5-[4-Cyano-2-(2-phenylethyl)phenyl]hydantoin

HRID 343949

반응식

HRID 343949 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[NH:13][C:12](=[O:14])[NH:11][C:10]2=[O:15])=[C:5]([C:16]#[C:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:4]=1)#[N:2]>CO.[C].[Pd]>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[NH:13][C:12](=[O:14])[NH:11][C:10]2=[O:15])=[C:5]([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:4]=1)#[N:2]

참가 물질

4

반응물 1

HCID 700765785-[4-Cyano-2-(2-phenylethynyl)phenyl]hydantoin

생성물 1

HCID 700747775-[4-Cyano-2-(2-phenylethyl)phenyl]hydantoin

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

A solution of 5-[4-cyano-2-(2-phenylethynyl)phenyl]hydantoin (100 mg, 0.33 mmol) in methanol (20 ml) was shaken with 10% palladium-carbon (10 mg) under an atmosphere of hydrogen for 24 hours at 60 p.s.i. The catalyst was removed by filtration to give 5-[4-cyano-2-(2-phenylethyl)phenyl]hydantoin as a colourless oil.

후처리

  1. customThe catalyst was removed by filtration

출처 및 근거

ORD 기록
ord-0ebda7467daf448680d696c08ef0e4de
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05863947

연결된 노트

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