Nitric Acid → HCID 54388458, 화합물

HRID 343951

반응식

HRID 343951 반응식
[NH2:1][CH:2]([C:6]1[CH:11]=[C:10]([OH:12])[CH:9]=[C:8]([OH:13])[CH:7]=1)[C:3]([OH:5])=[O:4].[N+:14]([O-])([OH:16])=[O:15].[OH-].[Na+]>O>[NH2:1][CH:2]([C:6]1[CH:7]=[C:8]([OH:13])[CH:9]=[C:10]([OH:12])[C:11]=1[N+:14]([O-:16])=[O:15])[C:3]([OH:5])=[O:4]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 14798Sodium HydroxideHCID 1080013,5-Dihydroxyphenylglycine

생성물 1

HCID 54388458HCID 54388458, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
-10 °C

실험 절차

2-Amino-2-(3,5-dihydroxyphenyl)-acetic acid (183 mg, 1 mmol) was added portionwise to stirred 5.5M nitric acid (2.5 ml, 15 mmol), which has been cooled to -10° C. in an ice/salt bath. The resulting brown solution was diluted with water (2 ml), neutralised with 2M sodium hydroxide, and purified by cationic exchange chromatography (as in Example 14) to give the title compound as a fluffy yellow solid, m.p. >280° C.

후처리

  1. custompurified by cationic exchange chromatography (as in Example 14)

출처 및 근거

ORD 기록
ord-d8b3701b5ba949b5bff96f29c7dfe01c
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05863947

연결된 노트

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