Diethyl (4-chloro-2-nitroanilino)methylphosphonate → Diethyl (2-amino-4-chloroanilino)methylphosphonate

HRID 343988

반응식

HRID 343988 반응식
[CH2:1]([O:3][P:4]([CH2:9][NH:10][C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=1[N+:18]([O-])=O)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].[H][H]>C(O)C.[Pt]>[CH2:1]([O:3][P:4]([CH2:9][NH:10][C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=1[NH2:18])(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2]

참가 물질

5

반응물 2

HCID 603785Diethyl (4-chloro-2-nitroanilino)methylphosphonateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 592810Diethyl (2-amino-4-chloroanilino)methylphosphonate

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 702Ethanol용매

실험 절차

A solution of [(4-Chloro-2-nitro-phenylamino)-methyl]-phosphonic acid diethyl ester (45g, 0.139 moles) in ethanol (500 mL) was treated under nitrogen at once with 5% Platinum on carbon (1.125 g) and then hydrogenated at 30° C. until the hydrogen uptake ceased. After purging the reaction vessel with nitrogen the reaction mixture was filtered through solka floc. The filter cake was washed with ethanol (100 mL) and the filtrate was used as such for next step without purification.

후처리

  1. customAfter purging the reaction vessel with nitrogen the reaction mixture
  2. filtrationwas filtered through solka floc
  3. washThe filter cake was washed with ethanol (100 mL)
  4. customwithout purification

출처 및 근거

ORD 기록
ord-31dbc0ac1def464896ff979474a6b51b
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05864040

연결된 노트

불러오는 중…