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Hydrochloric Acid → 2-[(R)-2-(1H-Indol-3-yl)-1-carboxymethyl-ethylamino]-N-(2-phenyl-ethyl)-ethylamine hydrochloride

HRID 344015
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반응식

HRID 344015 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][C@@H:11]([NH:16][CH2:17][CH2:18][N:19](C(OC(C)(C)C)=O)[CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:12][C:13]([OH:15])=[O:14])=[CH:2]1.[Cl:35]CCl.Cl>C(OCC)C>[ClH:35].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][C@@H:11]([NH:16][CH2:17][CH2:18][NH:19][CH2:20][CH2:21][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:12][C:13]([OH:15])=[O:14])=[CH:2]1
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참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 543206322-[(R)-2-(1H-Indol-3-yl)-1-carboxymethyl-ethylamino]-N-(t-butoxycarbonyl)-N-(2-phenyl-ethyl)-ethylamine

생성물 1

HCID 701993362-[(R)-2-(1H-Indol-3-yl)-1-carboxymethyl-ethylamino]-N-(2-phenyl-ethyl)-ethylamine hydrochloride

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Combine 2-[(R)-2-(1H-Indol-3-yl)-1-carboxymethyl-ethylamino]-N-(t-butoxycarbonyl)-N-(2-phenyl-ethyl)-ethylamine (1.64 g, 3.53 mmol) and dichloromethane (30 mL). Slowly pass hydrogen chloride gas through the solution for 20 minutes. Stir for 1 hour. Add diethyl ether (150 mL) to form a solid. Filter and dry under vacuum to give the title compound. Elem. Anal. calculated for C22H27N3O2.0.75 H2O: C, 58.70; H, 6.98; N, 9.14. Found: C, 58.71; H, 6.98; N, 9.14.

후처리

  1. filtrationFilter
  2. customdry under vacuum

출처 및 근거

ORD 기록
ord-e3a77c06f33c4a68bdb1d0652c7b971f
출처 데이터셋
uspto-grants-1999_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05864045

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