Aluminum(III) Chloride → HCID 15069388, 화합물

HRID 344143

반응식

HRID 344143 반응식
[Cl-].[Cl-].[Cl-].[Al+3].[CH3:5][CH:6]([CH3:38])[CH2:7][CH2:8][C:9]1[N:13]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[C:22]([C:27]([OH:29])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=3)=[CH:17][CH:16]=2)[C:12]2[CH:30]=[C:31]([O:36][CH3:37])[C:32]([O:34]C)=[CH:33][C:11]=2[N:10]=1>ClCCl>[CH3:5][CH:6]([CH3:38])[CH2:7][CH2:8][C:9]1[N:13]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[C:22]([C:27]([OH:29])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=3)=[CH:17][CH:16]=2)[C:12]2[CH:30]=[C:31]([O:36][CH3:37])[C:32]([OH:34])=[CH:33][C:11]=2[N:10]=1

참가 물질

4

반응물 2

HCID 6451240Aluminum(III) ChlorideHCID 150693604'-[(2-(3-Methylbutyl)-5,6-dimethoxy-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylic acid

생성물 1

HCID 15069388HCID 15069388, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3 g of aluminium trichloride are added to a suspension of 600 mg (1.3 mmol) of 4'-[(2-(3-methylbutyl)-5,6-dimethoxy-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylic acid in 50 ml of dry dichloromethane and the mixture is heated under reflux for 15 minutes. The solvent is then distilled off, the residue is filtered off under suction, washed using 30 ml of water and dried. 360 mg (62% of theoretical) of a mixture of the isomeric products is obtained after chromatographing over silica gel (eluting agent: dichloromethane/ethanol=9:1).

후처리

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 15 minutes
  3. distillationThe solvent is then distilled off
  4. filtrationthe residue is filtered off under suction
  5. washwashed
  6. customdried
  7. addition360 mg (62% of theoretical) of a mixture of the isomeric products
  8. customis obtained after chromatographing over silica gel (eluting agent: dichloromethane/ethanol=9:1)

출처 및 근거

ORD 기록
ord-ab3b77ca0d30432a9ebac45cccfa1e26
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05864043

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