2-Chloroanisole → 6-Bromo-1-(3-chloro-4-methoxyphenyl)-1-hexanone

HRID 344260노트

반응식

HRID 344260 반응식
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7](Cl)=[O:8].[Cl:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[O:17][CH3:18].[Cl-].[Al+3].[Cl-].[Cl-]>>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([C:15]1[CH:14]=[CH:13][C:12]([O:17][CH3:18])=[C:11]([Cl:10])[CH:16]=1)=[O:8]

참가 물질

4

반응물 3

HCID 130112-ChloroanisoleHCID 898486-Bromohexanoyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 544516236-Bromo-1-(3-chloro-4-methoxyphenyl)-1-hexanone수율 32.8%

실험 절차

6-Bromohexanoyl chloride (2.0 g), 2-chloroanisole (1.17 g) and aluminum chloride (1.12 g) were reacted and treated in the same manner as in Preparation Example 105 to give 0.86 g of 6-bromo-1-(3-chloro-4-methoxyphenyl)-1-hexanone.

후처리

  1. additiontreated in the same manner as in Preparation Example 105

출처 및 근거

ORD 기록
ord-6677ed8115f046db8e3284ab9b2038e1
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05864039

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