Hydrazine hydrate (1:1) → 4-Amino-N-(1-(6-aminohexyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide

HRID 344392

반응식

HRID 344392 반응식
[NH2:1][C:2]1[C:34]([Cl:35])=[CH:33][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][N:22]3C(=O)C4C(=CC=CC=4)C3=O)[CH2:12][CH2:11]2)=[O:7])=[C:4]([O:36][CH3:37])[CH:3]=1.O.NN>>[NH2:1][C:2]1[C:34]([Cl:35])=[CH:33][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][NH2:22])[CH2:14][CH2:15]2)=[O:7])=[C:4]([O:36][CH3:37])[CH:3]=1

참가 물질

3

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 545206764-amino-5-chloro-N-(1-(6-(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)hexyl)-piperidin-4-ylmethyl)-2-methoxybenzamide

생성물 1

HCID 536836374-Amino-N-(1-(6-aminohexyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide수율 112.7%

실험 절차

4-Amino-5-chloro-N-(1-(6-(2,3-dihydro-1,3-dioxo-1 H-isoindol-2-yl)hexyl)piperidin-4-ylmethyl)-2-methoxybenzamide (15.9 g) as starting compound and hydrazine monohydrate (2.2 ml) were reacted and treated in the same manner as in Example 117 to give 13.5 g of 4-amino-N-(1-(6-aminohexyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide.

후처리

  1. customwere reacted
  2. additiontreated in the same manner as in Example 117

출처 및 근거

ORD 기록
ord-f945036bc7814c629ca548b08477c3f5
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05864039

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