O-Methylhydroxylamine → 0-Methyl-2-(4,6-dimethoxy-2-pyrimidinyloxy)benzaldehyde

HRID 344569노트

반응식

HRID 344569 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][C:12]2[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=2[CH:14]=[O:15])[N:4]=1.[CH3:20]ON>CO>[CH3:20][C:12]1([O:11][C:5]2[N:4]=[C:3]([O:2][CH3:1])[CH:8]=[C:7]([O:9][CH3:10])[N:6]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:13]1[CH:14]=[O:15]

참가 물질

4

반응물 2

HCID 4113O-MethylhydroxylamineHCID 820623Benzaldehyde, 2-[(4,6-dimethoxy-2-pyrimidinyl)oxy]-

생성물 1

HCID 885126260-Methyl-2-(4,6-dimethoxy-2-pyrimidinyloxy)benzaldehyde수율 103.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In 100 ml of methanol, 5.2 g of 2-(4,6-dimethoxy-2-pyrimidinyloxy)benzaldehyde and 1.0 g of methoxyamine were dissolved. The solution was stirred at room temperature for 2 hours. After the methanol was distilled out under reduced pressure, the resulting residue was purified by silica gel chromatography (developer: n-hexane:ethyl acetate=10:1) to obtain 5.7 g of 0-methyl-2-(4,6-dimethoxy-2-pyrimidinyloxy)benzaldehyde as an oily substance.

후처리

  1. distillationAfter the methanol was distilled out under reduced pressure
  2. customthe resulting residue was purified by silica gel chromatography (developer: n-hexane:ethyl acetate=10:1)

출처 및 근거

ORD 기록
ord-3b97b9e1659946e78fab041bfe9d304a
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05053070

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