Hydrochloric Acid → Toluene, alpha-chloro-2,3,4-trimethoxy-

HRID 344708

반응식

HRID 344708 반응식
[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=[CH:7][C:4]=1[CH2:5]O.[ClH:15]>O>[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=[CH:7][C:4]=1[CH2:5][Cl:15]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 123571(2,3,4-Trimethoxyphenyl)methanol

생성물 1

HCID 97491Toluene, alpha-chloro-2,3,4-trimethoxy-

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
0 °C

실험 절차

5.0 g (4.34 mmols) of 2,3,4-trimethoxybenzyl alcohol was dropwise added to 10 ml of conc. hydrochloric acid under stirring at 0° C. The mixture was stirred at 0° C. for further 5 minutes. After the reaction, water was added to the mixture followed by extraction of the solution with diethyl ether. The diethyl ether layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to afford 4.80 g of 2,3,4-trimethoxybenzyl chloride as a crude product.

후처리

  1. stirringThe mixture was stirred at 0° C. for further 5 minutes
  2. additionwas added to the mixture
  3. extractionfollowed by extraction of the solution with diethyl ether
  4. dry with materialThe diethyl ether layer was dried over anhydrous sodium sulfate
  5. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-a3a565d166b2461da24bbc4b59201e1e
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05053408

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