1-Fluoro-2-nitrobenzene → HCID 19809395, 화합물

HRID 345000노트

반응식

HRID 345000 반응식
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[N:11]1([CH2:17][C:18]2[NH:19][CH:20]=[CH:21][N:22]=2)[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1.C(N(CC)C(C)C)(C)C>C(#N)C>[N:11]1([CH2:17][C:18]2[N:22]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[N+:8]([O-:10])=[O:9])[CH:21]=[CH:20][N:19]=2)[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1

참가 물질

5

반응물 3

HCID 738951-Fluoro-2-nitrobenzeneHCID 81531DiisopropylethylamineHCID 2722464-(1H-imidazol-2-ylmethyl)morpholine

생성물 1

HCID 19809395HCID 19809395, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Combine 10 g of 2-fluoronitrobenzene, 13 g of 2-((4-morpholinyl)methyl)-imidazole, 18 mL of N,N-diisopropyl ethylamine, and 150 mL of acetonitrile, and heat at reflux for 48 hr. Remove the solvent under vacuum, and dissolve the residue in 500 mL of 2N H2SO4. Wash the aqueous portion with 400 mL of ether, basify with K2CO3, and extract with two 400 mL portions of CH2Cl2. Combine extracts, dry over MgSO4, charcoal treat and remove the solvent under vacuum to provide the title compound.

후처리

  1. temperatureat reflux for 48 hr
  2. customRemove the solvent under vacuum
  3. dissolutiondissolve the residue in 500 mL of 2N H2SO4
  4. washWash the aqueous portion with 400 mL of ether
  5. extractionextract with two 400 mL portions of CH2Cl2
  6. dry with materialCombine extracts, dry over MgSO4, charcoal
  7. additiontreat
  8. customremove the solvent under vacuum

출처 및 근거

ORD 기록
ord-277bbfb458bd45cc9b91d0dc82f80c5c
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05055465

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