Acetic Acid → 3-(Acetyloxy)-2-[(acetyloxy)methyl]-2-methylpropanoic acid

HRID 34518

반응식

HRID 34518 반응식
[OH:1][CH2:2][C:3]([CH2:8][OH:9])([CH3:7])[C:4]([OH:6])=[O:5].[C:10](OC(=O)C)(=[O:12])[CH3:11].[C:17](O)(=[O:19])[CH3:18]>>[C:10]([O:1][CH2:2][C:3]([CH2:8][O:9][C:17](=[O:19])[CH3:18])([CH3:7])[C:4]([OH:6])=[O:5])(=[O:12])[CH3:11]

참가 물질

4

반응물 3

HCID 176Acetic AcidHCID 7918Acetic AnhydrideHCID 78501Dimethylolpropionic acid

생성물 1

HCID 224578423-(Acetyloxy)-2-[(acetyloxy)methyl]-2-methylpropanoic acid

실험 절차

268 g (2 moles) of 2,2-bis-hydroxymethyl propionic acid are refluxed for 10 hours in 800 ml of glacial acetic acid and 416 ml (4.4 moles) of acetic acid anhydride. The reaction solution is freed from the solvent in vacuo. The oily residue is stirred with 1500 ml of petroleum ether, the carboxylic acid ester is crystallizing out. It is filtered off under suction and washed with petroleum ether. Yield 420 g (96% of the theoretical); Mp. 85° C.

후처리

  1. customthe carboxylic acid ester is crystallizing out
  2. filtrationIt is filtered off under suction
  3. washwashed with petroleum ether

출처 및 근거

ORD 기록
ord-514729e647c04c69a19605290443db05
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04762777

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