1-Methylcyclohexyl 2-(p-nitrophenyl)propionate → 1-Methylcyclohexyl 2-(p-aminophenyl)-propionate

HRID 34538

반응식

HRID 34538 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:21])[C:11]([O:13][C:14]2([CH3:20])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[O:12])=[CH:6][CH:5]=1)([O-])=O.[H][H]>C(O)C.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:21])[C:11]([O:13][C:14]2([CH3:20])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[O:12])=[CH:6][CH:5]=1

참가 물질

5

반응물 2

HCID 540684921-Methylcyclohexyl 2-(p-nitrophenyl)propionateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 137540711-Methylcyclohexyl 2-(p-aminophenyl)-propionate수율 67.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A stirred solution of 34.9 g of 1-methylcyclohexyl 2-(p-nitrophenyl)-propionate in 250 ml of absolute ethanol was hydrogenated at atmospheric pressure in the presence of 10% palladium on carbon catalyst. After the uptake of hydrogen gas was complete, the catalyst was filtered off through celite and the filtrate was evaporated to dryness. Trituration of the residue with petroleum ether gave 21.02 g (67% yield) of 1-methylcyclohexyl 2-(p-aminophenyl)-propionate as creamy white crystals melting at 85°-87° C.

후처리

  1. filtrationthe catalyst was filtered off through celite
  2. customthe filtrate was evaporated to dryness

출처 및 근거

ORD 기록
ord-15fc9e5b04644708b922aada49328d83
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04762840

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