Hydrochloric Acid → (2,6-Dimethylphenyl)methanol

HRID 345780노트

반응식

HRID 345780 반응식
C([O:3][C:4](=O)[C:5]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:6]=1[CH3:12])C.[H-].[H-].[H-].[H-].[Li+].[Al+3].[H-].Cl>C(OCC)C.O>[CH3:12][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]([CH3:11])[C:5]=1[CH2:4][OH:3]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 166653HydrideHCID 520807Ethyl 2,6-dimethylbenzoateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 186748(2,6-Dimethylphenyl)methanol수율 77.5%

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매2회

실험 절차

17 g of 2,6-dimethyl benzoic acid ethyl ester (0.095 mole) dissolved in 50 ml of ethyl ether are added dropwise as a function of the vigor of reflux to a suspension of 3.72 g (0.095 mole) of LiAlH4 in 100 ml of ether. When the addition is complete, the mixture is heated at reflux for 2h and left to stand overnight. Excess hydride is decomposed by the gradual addition of water (while cooling the flask in an ice-water bath), then 10% HCl. After the usual work-up, the product is crystallized from petroleum ether. 10 g of product are obtained. M.p.=84°. Yield 77.5%.

후처리

  1. additionare added dropwise as a function of the vigor
  2. additionWhen the addition
  3. temperaturethe mixture is heated
  4. waitleft
  5. customAfter the usual work-up, the product is crystallized from petroleum ether

출처 및 근거

ORD 기록
ord-0da8fb96850b4fa4af3bae9273f05dea
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05059614

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