Potassium Carbonate → 1,2-Dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane

HRID 345828노트

반응식

HRID 345828 반응식
C([N:4]1[CH2:11][C:10]2([CH3:12])[CH:6]([CH2:7][O:8][N:9]2[CH3:13])[CH2:5]1)(=O)C.[OH-].[Na+].C([O-])([O-])=O.[K+].[K+]>O>[CH3:12][C:10]12[CH2:11][NH:4][CH2:5][CH:6]1[CH2:7][O:8][N:9]2[CH3:13]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 150700177-Acetyl-1,2-dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane

생성물 1

HCID 150700181,2-Dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane

시약·촉매·용매 1

HCID 962Water용매

실험 절차

11.8 g (64 mmol) of 7-acetyl-1,2-dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane are heated under reflux with 12 g of NaOH in 36 ml of water overnight. The mixture is saturated with K2CO3 and extracted several times with CHCl3, the extract is dried over K2CO3 and concentrated and the residue is distilled.

후처리

  1. extractionextracted several times with CHCl3
  2. dry with materialthe extract is dried over K2CO3
  3. concentrationconcentrated
  4. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-b9c6520b46094dc98b1ea6c72a4a8901
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05059597

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