Sodium Hydroxide → trans-3-Ethylamino-4-methylthio-pyrrolidine
반응식
C([N:9]1[CH2:13][C@@H:12]([S:14][CH3:15])[C@H:11]([NH:16][CH2:17][CH3:18])[CH2:10]1)(=O)C1C=CC=CC=1.[OH-].[Na+]>>[CH2:17]([NH:16][C@H:11]1[C@H:12]([S:14][CH3:15])[CH2:13][NH:9][CH2:10]1)[CH3:18]참가 물질
3
실험 절차
6.0 g (22 mmol) of 1-benzoyl-trans-3-ethylamino-4-methylthio-pyrrolidine are stirred vigorously with 22 ml of 5N NaOH at 100° C. for 24 hours, until the conversion is homogeneous. The mixture is then extracted with 3×80 ml of ether and the extract is dried over sodium sulphate and concentrated on a rotary evaporator. The crude product is distilled through a micro-puncture column.
후처리
- extractionThe mixture is then extracted with 3×80 ml of ether
- dry with materialthe extract is dried over sodium sulphate
- concentrationconcentrated on a rotary evaporator
- distillationThe crude product is distilled through a micro-puncture column
출처 및 근거
- ORD 기록
- ord-5129d7ad6dc1473681f55b532755023e
- 출처 데이터셋
- uspto-grants-1991_10
- 특허 번호
- US05059597
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