Water → HCID 178471932, 화합물

HRID 345848노트

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HRID 345848 반응식
[Cl:1][C:2]1[C:19]([F:20])=[C:18]([Cl:21])[CH:17]=[C:16]([F:22])[C:3]=1[C:4]([C:6](=[CH:12]OCC)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].[F:23][C:24]1[CH:30]=[C:29]([F:31])[CH:28]=[CH:27][C:25]=1[NH2:26].O>C(O)C>[Cl:1][C:2]1[C:19]([F:20])=[C:18]([Cl:21])[CH:17]=[C:16]([F:22])[C:3]=1[C:4]([C:6](=[CH:12][NH:26][C:25]1[CH:27]=[CH:28][C:29]([F:31])=[CH:30][C:24]=1[F:23])[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]

참가 물질

5

반응물 3

HCID 962WaterHCID 97092,4-DifluoroanilineHCID 53750212Ethyl 2-(2,4-dichloro-3,6-difluorobenzoyl)-3-ethoxyacrylate

생성물 1

HCID 178471932HCID 178471932, 화합물수율 92.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

35.3 g of ethyl 2-(2,4-dichloro-3,6-difluorobenzoyl)-3-ethoxyacrylate are dissolved in 120 ml of ethanol, and 12.9 g of 2,4-difluoroaniline are added dropwise, while cooling with ice. The mixture is stirred at room temperature for 1.5 hours, 120 ml of water are added, while cooling, and the precipitate is filtered off with suction, rinsed with ethanol/H2O (1:1) and dried. 40.5 g of ethyl 2-(2,4-dichloro-3,6-difluorobenzoyl)-3-(2,4-difluorophenylamino)-acrylate are obtained, melting point: 84°-86° C.

후처리

  1. temperaturewhile cooling with ice
  2. temperaturewhile cooling
  3. filtrationthe precipitate is filtered off with suction
  4. washrinsed with ethanol/H2O (1:1)
  5. customdried

출처 및 근거

ORD 기록
ord-b72bd32b49974589b37dc18ecba3b422
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05059597

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