Benzyl Bromide → 1-Phenyl-2-benzyl-3,4-dihydroisoquinolinium bromide

HRID 345854

반응식

HRID 345854 반응식
[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH2:10][CH2:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:17]([Br:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(#N)C>[Br-:24].[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH2:10][CH2:9][N+:8]=2[CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 7498Benzyl BromideHCID 6099261-Phenyl-3,4-dihydroisoquinoline

생성물 1

HCID 108096381-Phenyl-2-benzyl-3,4-dihydroisoquinolinium bromide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

The mixture of 1-phenyl-3,4-dihydroisoquinoline (292.0 g) and benzyl bromide (176 ml) in acetonitrile (3 l) was refluxed for 1 hour. After cooling the mixture to room temperature, the solvent was evaporated in vacuo. The residue was triturated with diethyl ether (1 l) to give 1-phenyl-2-benzyl-3,4-dihydroisoquinolinium bromide (471.2 g).

후처리

  1. temperaturewas refluxed for 1 hour
  2. customthe solvent was evaporated in vacuo
  3. customThe residue was triturated with diethyl ether (1 l)

출처 및 근거

ORD 기록
ord-d03d24d666134bcbb7e9887a3efdf6d4
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05059608

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