4-Chlorobutyronitrile → HCID 178478461, 화합물

HRID 345935노트

반응식

HRID 345935 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][C:5]#[N:6].[N-:7]=[N+:8]=[N-:9].[Na+].[Cl-].[NH4+].[OH-].[Na+]>CN(C)C=O>[Cl:1][CH2:2][CH2:3][CH2:4][C:5]1[NH:9][N:8]=[N:7][N:6]=1

참가 물질

6

반응물 4

HCID 123364-ChlorobutyronitrileHCID 14798Sodium HydroxideHCID 25517Ammonium ChlorideHCID 33557Sodium Azide

생성물 1

HCID 178478461HCID 178478461, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
140 °C

실험 절차

A mixture of 3.5 g of 4-chlorobutyronitrile, 2.3 g of sodium azide and 1.9 g of ammonium chloride in 50 ml of dimethyl-formamide is stirred at 140° C. for 20 hours. The reaction mixture is poured onto ice, basified with 1N sodium hydroxide and extracted twice with ethyl acetate. The aqueous fraction is acidified with acetic acid and extracted with ethylacetate. Evaporation of the ethyl acetate gives 5-(3-chloropropyl)-tetrazole which is used directly in the next step.

후처리

  1. additionThe reaction mixture is poured onto ice
  2. extractionextracted twice with ethyl acetate
  3. extractionextracted with ethylacetate
  4. customEvaporation of the ethyl acetate

출처 및 근거

ORD 기록
ord-0b5be6729b46436084030504bcb87386
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05059610

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