3-Pyridinecarboxaldehyde → HCID 53813079, 화합물

HRID 346007노트

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HRID 346007 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[O:9][CH2:8][CH2:7][C:6]2=[O:13].[N:14]1[CH:19]=[CH:18][CH:17]=[C:16]([CH:20]=O)[CH:15]=1.N1CCCC1>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[O:9][CH2:8][C:7](=[CH:20][C:16]1[CH:15]=[N:14][CH:19]=[CH:18][CH:17]=1)[C:6]2=[O:13]

참가 물질

5

반응물 3

HCID 103713-PyridinecarboxaldehydeHCID 31268PyrrolidineHCID 46121686-methoxy-3,4-dihydro-2H-1-benzopyran-4-one

생성물 1

HCID 53813079HCID 53813079, 화합물수율 57%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
25 °C

실험 절차

To a 25° C. mixture of 20.0 g (0.112 mol) of 6-methoxy-4-chromanone and 18.09 g (0.169 mol) of 3-pyridinecarbaldehyde in 100 ml of methanol was added 14.1 ml (0.169 mol) of pyrrolidine. The resultant solution was allowed to stir 60 hours at 25° C., cooled to 0° C. and filtered to yield 17.07 g (57%) of the title compound, m.p. 127°-131° C.

후처리

  1. temperaturecooled to 0° C.
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-0d2f33d50ff548f2877193aa367d62a4
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05059609

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