Hydrochloric Acid → Z-4-(3-chloroprop-2-en-1-yl)-2,3,5,6-tetrafluorobenzyl alcohol
반응식
[Cl:1][CH:2]=[CH:3][CH2:4][C:5]1[C:18]([F:19])=[C:17]([F:20])[C:8]([CH2:9][O:10]C2CCCCO2)=[C:7]([F:21])[C:6]=1[F:22].Cl>CO.O>[Cl:1]/[CH:2]=[CH:3]\[CH2:4][C:5]1[C:6]([F:22])=[C:7]([F:21])[C:8]([CH2:9][OH:10])=[C:17]([F:20])[C:18]=1[F:19]참가 물질
5
실험 절차
The tetrahydropyranyl ether prepared in stage (ii) was dissolved in methanol (30 cm3), and to the stirred solution was added a catalytic amount of concentrated hydrochloric acid. After stirring for two hours, the reaction mixture was diluted with water, and extracted with ethyl acetate. The organic layer was washed and dried, and the solvent evaporated under reduced pressure to give Z-4-(3-chloroprop-2-en-1-yl)-2,3,5,6-tetrafluorobenzyl alcohol (0.6 g) as a colourless oil, which solidified on standing.
후처리
- extractionextracted with ethyl acetate
- washThe organic layer was washed
- customdried
- customthe solvent evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-df994d04c0054c998bbdfece7eb174fb
- 출처 데이터셋
- uspto-grants-1988_08
- 특허 번호
- US04762835
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