Ethylene → 1-(2-Bromoethyl)-3,5-dimethyl Adamantane

HRID 346102

반응식

HRID 346102 반응식
Br[C:2]12[CH2:11][C:6]3([CH3:12])[CH2:7][CH:8]([CH2:10][C:4]([CH3:13])([CH2:5]3)[CH2:3]1)[CH2:9]2.[Br-:14].[Al+3].[Br-].[Br-].[CH2:18]=[CH2:19]>CCCCCC>[Br:14][CH2:18][CH2:19][C:8]12[CH2:10][C:4]3([CH3:13])[CH2:3][CH:2]([CH2:11][C:6]([CH3:12])([CH2:5]3)[CH2:7]1)[CH2:9]2

참가 물질

5

반응물 3

HCID 6325EthyleneHCID 983171-Bromo-3,5-dimethyladamantaneHCID 166749Bromhydrol

생성물 1

HCID 150687671-(2-Bromoethyl)-3,5-dimethyl Adamantane수율 48%

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

Mix 1.4 mol of 1-bromo-3,5-dimethyl adamantane (I) in hexane with 0.6 mol of aluminum bromide at -75° C. Subsequently, pass ethylene through the solution for 20-30 minutes, stir for 5 min., and pour the reaction mixture onto ice water. Extract with ether, dry the organic phase and evaporate to dryness. Recrystallize the residue from methanol. (Yield: 48%).

후처리

  1. customfor 20-30 minutes
  2. additionpour the reaction mixture onto ice water
  3. extractionExtract with ether
  4. customdry the organic phase
  5. customevaporate to dryness
  6. customRecrystallize the residue from methanol

출처 및 근거

ORD 기록
ord-8ea37ed7204243fe814166548c4d8d15
출처 데이터셋
uspto-grants-1991_10
특허 번호
US05061703

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