4,5-Dichloro-2-fluoroaniline → 4-[(3,4-Dichloro-6-fluorophenyl)amino]-7-fluoro-6-nitroquinazoline

HRID 346416

반응식

HRID 346416 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:6]([F:10])=[CH:7][C:8]=1[Cl:9])[NH2:5].Cl[C:12]1[C:21]2[C:16](=[CH:17][C:18]([F:25])=[C:19]([N+:22]([O-:24])=[O:23])[CH:20]=2)[N:15]=[CH:14][N:13]=1>C(O)(C)C>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][C:12]2[C:21]3[C:16](=[CH:17][C:18]([F:25])=[C:19]([N+:22]([O-:24])=[O:23])[CH:20]=3)[N:15]=[CH:14][N:13]=2)[C:6]([F:10])=[CH:7][C:8]=1[Cl:9]

참가 물질

4

반응물 2

HCID 2230914,5-Dichloro-2-fluoroanilineHCID 106093584-Chloro-7-fluoro-6-nitroquinazoline

생성물 1

HCID 111761854-[(3,4-Dichloro-6-fluorophenyl)amino]-7-fluoro-6-nitroquinazoline수율 78%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

3,4-Dichloro-6-fluoroaniline (1 equivalent) was reacted with 4-chloro-7-fluoro-6-nitroquinazoline (3.5 equivalents), in iso-propylalcohol. After filtration, 4-[(3,4-dichloro-6-fluorophenyl)amino]-7-fluoro-6-nitroquinazoline was obtained in 78% yield.

후처리

  1. filtrationAfter filtration

출처 및 근거

ORD 기록
ord-1042ad855505453485b72441af00c3ae
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07172749B2

연결된 노트

불러오는 중…