Hydrochloric Acid → HCID 21081843, 화합물

HRID 346511

반응식

HRID 346511 반응식
[NH:1]([C:3]1[N:8]=[N:7][C:6]([N:9]([CH3:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:5][CH:4]=1)[NH2:2].[Cl:17][C:18]1[N:23]=[C:22]([C:24](O)=[O:25])[CH:21]=[CH:20][CH:19]=1.Cl>C(Cl)Cl>[Cl:17][C:18]1[N:23]=[C:22]([C:24]([NH:2][NH:1][C:3]2[N:8]=[N:7][C:6]([N:9]([CH3:16])[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:5][CH:4]=2)=[O:25])[CH:21]=[CH:20][CH:19]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 208126-Chloropicolinic acidHCID 210818446-Hydrazinyl-N-methyl-N-phenyl-3-pyridazinamine

생성물 1

HCID 21081843HCID 21081843, 화합물수율 30.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 6-hydrazino-N-methyl-N-phenylpyridazine-3-amine (1.14 g) in methylene chloride (10 ml), 6-chloropicolic acid (0.83 g) and WSCD hydrochloride (1.22 g) were added, and the mixture was stirred at room temperature overnight. The reaction solution was purified by silica gel column chromatography (eluent: chloroform) to obtain 6-chloro-N′-{6-[methyl(phenyl)amino]pyridazin-3-yl}pyridine-2-carbohydrazide (0.57 g). This compound (0.56 g) was stirred at 150° C. overnight in xylene (20 ml), and the reaction solution was concentrated to obtain 3-(chloropyridin-2-yl)-N-methyl-N-phenyl-1,2,4-triazolo[4,3-b]pyridazine-6-amine (0.54 g) as colorless solids.

후처리

  1. customThe reaction solution was purified by silica gel column chromatography (eluent: chloroform)

출처 및 근거

ORD 기록
ord-0d15d04f87134a0ea1bdf49eb3d5b4f2
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07173033B2

연결된 노트

불러오는 중…