Potassium Carbonate → 4-(3-chlorophenyl)-6-(3-iodobenzoyl)-2(1H)-quinolinone

HRID 346984노트

반응식

HRID 346984 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([C:20]4[CH:25]=[CH:24][CH:23]=[C:22]([I:26])[CH:21]=4)=[O:19])[CH:16]=3)[N:11]=[C:10]([O:27]C)[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+]>Cl.C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18](=[O:19])[C:20]4[CH:25]=[CH:24][CH:23]=[C:22]([I:26])[CH:21]=4)[CH:16]=3)[NH:11][C:10](=[O:27])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 11430Potassium CarbonateHCID 21082028[4-(3-Chlorophenyl)-2-methoxy-6-quinolinyl](3-iodophenyl)-methanone

생성물 1

HCID 210820354-(3-chlorophenyl)-6-(3-iodobenzoyl)-2(1H)-quinolinone수율 88%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of intermediate (73) (0.0304 mol) in HCl 3N (150 ml) and THF (70 ml) was stirred and refluxed overnight, brought to room temperature, poured out into ice water and basified with potassium carbonate. The precipitate was filtered, washed with 2-propanone and dried, yielding 13 g (88%) of 4-(3-chlorophenyl)-6-(3-iodobenzoyl)-2(1H)-quinolinone (intermediate 74).

후처리

  1. temperaturerefluxed overnight
  2. custombrought to room temperature
  3. filtrationThe precipitate was filtered
  4. washwashed with 2-propanone
  5. customdried

출처 및 근거

ORD 기록
ord-df125b2042124c39917f6eb35422eafd
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07173040B2

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